There is a huge amount of scientific studies presenting the role of high-frequency heart rate variability (HF-HRV), a marker of parasympathetic nervous system activity, in different physiological states and disorders.
But what if you could increase HF-HRV by 46.8% in just 5 minutes?*
Aganov S, Nayshtetik E, Nagibin V, Lebed Y. Pure purr virtual reality technology: measuring heart rate variability and anxiety levels in healthy volunteers affected by moderate stress. Archives of Medical Science. 2020. doi:10.5114/aoms.2020.93239.
Golbidi S, Frisbee JC, Laher I. Chronic stress impacts the cardiovascular system: animal models and clinical outcomes. Am J Physiol Heart Circ Physiol. 2015;308(12):H1476-H1498. doi:10.1152/ajpheart.00859.2014
Ginty AT, Kraynak TE, Fisher JP, Gianaros PJ. Cardiovascular and autonomic reactivity to psychological stress: Neurophysiological substrates and links to cardiovascular disease. Auton Neurosci. 2017;207:2-9. doi:10.1016/j.autneu.2017.03.003
Gianaros PJ, Jennings JR. Host in the machine: A neurobiological perspective on psychological stress and cardiovascular disease. Am Psychol. 2018;73(8):1031-1044. doi:10.1037/amp0000232
Fauvel JP. Stress mental et système cardiovasculaire [Cardiovascular impact of psychological stress]. Ann Cardiol Angeiol (Paris). 2002;51(2):76-80. doi:10.1016/s0003-3928(02)00070-7
Woody A, Figueroa WS, Benencia F, Zoccola PM. Stress-Induced Parasympathetic Control and Its Association With Inflammatory Reactivity. Psychosom Med. 2017;79(3):306-310. doi:10.1097/PSY.0000000000000426
Cooper TM, McKinley PS, Seeman TE, Choo TH, Lee S, Sloan RP. Heart rate variability predicts levels of inflammatory markers: Evidence for the vagal anti-inflammatory pathway. Brain Behav Immun. 2015;49:94-100. doi:10.1016/j.bbi.2014.12.017
Lockwood KG, Jennings JR, Matthews KA. Psychophysiological correlates of systemic inflammation in black and white men. Brain Behav Immun. 2017;59:93-102. doi:10.1016/j.bbi.2016.08.013
Murdock KW, LeRoy AS, Fagundes CP. Trait hostility and cortisol sensitivity following a stressor: The moderating role of stress-induced heart rate variability. Psychoneuroendocrinology. 2017;75:222-227. doi:10.1016/j.psyneuen.2016.10.014
Jarczok MN, Koenig J, Mauss D, Fischer JE, Thayer JF. Lower heart rate variability predicts increased level of C-reactive protein 4 years later in healthy, nonsmoking adults. J Intern Med. 2014;276(6):667-671. doi:10.1111/joim.12295
Ng C, Malcolm A, Hansen R, Kellow J. Feeding and colonic distension provoke altered autonomic responses in irritable bowel syndrome. Scand J Gastroenterol. 2007;42(4):441-446. doi:10.1080/00365520600965749
Tian G, Xiong L, Leung H, Soo Y, Leung T, Wong LK. Beat-to-beat blood pressure variability and heart rate variability in relation to autonomic dysregulation in patients with acute mild-moderate ischemic stroke. J Clin Neurosci. 2019;64:187-193. doi:10.1016/j.jocn.2019.03.003
Allen TM, Struemph KL, Toledo-Tamula MA, et al. The Relationship Between Heart Rate Variability, Psychological Flexibility, and Pain in Neurofibromatosis Type 1. Pain Pract. 2018;18(8):969-978. doi:10.1111/papr.12695
Lotufo PA, Valiengo L, Benseñor IM, Brunoni AR. A systematic review and meta-analysis of heart rate variability in epilepsy and antiepileptic drugs. Epilepsia. 2012;53(2):272-282. doi:10.1111/j.1528-1167.2011.03361.x
Rodrigues S, Paiva JS, Dias D, Cunha JPS. Stress among on-duty firefighters: an ambulatory assessment study. PeerJ. 2018;6:e5967. Published 2018 Dec 11. doi:10.7717/peerj.5967
Landolt K, Maruff P, Horan B, et al. Chronic work stress and decreased vagal tone impairs decision making and reaction time in jockeys. Psychoneuroendocrinology. 2017;84:151-158. doi:10.1016/j.psyneuen.2017.07.238
Giese-Davis J, Wilhelm FH, Tamagawa R, et al. Higher vagal activity as related to survival in patients with advanced breast cancer: an analysis of autonomic dysregulation. Psychosom Med. 2015;77(4):346-355. doi:10.1097/PSY.0000000000000167
Asher A, Palmer JL, Yadav RR, et al. The effects of a brief relaxation program on symptom distress and heart rate variability in cancer patients. PM R. 2010;2(7):636-641. doi:10.1016/j.pmrj.2010.04.026
Wilson ST, Chesin M, Fertuck E, et al. Heart rate variability and suicidal behavior. Psychiatry Res. 2016;240:241-247. doi:10.1016/j.psychres.2016.04.033
Adler-Neal AL, Waugh CE, Garland EL, Shaltout HA, Diz DI, Zeidan F. The Role of Heart Rate Variability in Mindfulness-Based Pain Relief [published online ahead of print, 2019 Aug 1]. J Pain. 2019;S1526-5900(19)30773-4. doi:10.1016/j.jpain.2019.07.003
Casement MD, Goldstein TR, Merranko J, Gratzmiller SM, Franzen PL. Sleep and Parasympathetic Activity During Rest and Stress in Healthy Adolescents and Adolescents With Bipolar Disorder. Psychosom Med. 2019;81(9):782-790. doi:10.1097/PSY.0000000000000737
Chang CC, Tzeng NS, Yeh CB, Kuo TBJ, Huang SY, Chang HA. Effects of depression and melatonergic antidepressant treatment alone and in combination with sedative-hypnotics on heart rate variability: Implications for cardiovascular risk. World J Biol Psychiatry. 2018;19(5):368-378. doi:10.1080/15622975.2017.1294765
D'Souza JM MA, Wardle M, Green CE, Lane SD, Schmitz JM, Vujanovic AA. Resting Heart Rate Variability: Exploring Associations With Symptom Severity in Adults With Substance Use Disorders and Posttraumatic Stress. J Dual Diagn. 2019;15(1):2-7. doi:10.1080/15504263.2018.1526431
Ramírez E, Ortega AR, Reyes Del Paso GA. Anxiety, attention, and decision making: The moderating role of heart rate variability. Int J Psychophysiol. 2015;98(3 Pt 1):490-496. doi:10.1016/j.ijpsycho.2015.10.007
Soder HE, Wardle MC, Schmitz JM, Lane SD, Green C, Vujanovic AA. Baseline resting heart rate variability predicts post-traumatic stress disorder treatment outcomes in adults with co-occurring substance use disorders and post-traumatic stress. Psychophysiology. 2019;56(8):e13377. doi:10.1111/psyp.13377
Beauchaine TP, Thayer JF. Heart rate variability as a transdiagnostic biomarker of psychopathology. Int J Psychophysiol. 2015;98(2 Pt 2):338-350. doi:10.1016/j.ijpsycho.2015.08.004
Chang HA, Chang CC, Tzeng NS, Kuo TB, Lu RB, Huang SY. Heart rate variability in unmedicated patients with bipolar disorder in the manic phase. Psychiatry Clin Neurosci. 2014;68(9):674-682. doi:10.1111/pcn.12178
Pittig A, Arch JJ, Lam CW, Craske MG. Heart rate and heart rate variability in panic, social anxiety, obsessive-compulsive, and generalized anxiety disorders at baseline and in response to relaxation and hyperventilation. Int J Psychophysiol. 2013;87(1):19-27. doi:10.1016/j.ijpsycho.2012.10.012
Nazarewicz J, Verdejo-Garcia A, Giummarra MJ. Sympathetic pain? A role of poor parasympathetic nervous system engagement in vicarious pain states. Psychophysiology. 2015;52(11):1529-1537. doi:10.1111/psyp.12516